Shakthisree Gopalan was a native of Kochi, Kerala. Shakthisree had her studies in the Rajagiri Public School, Kalamassaey. After her studies, Shakthisree moved to Chennai whereby she continued her Architecture degree at the Anna University School of Planning and Architecture. At the age of 13, Shakthisree Gopalan is already trained in the field of Carnatic music. In 11th grade, she already engaged herself in the SS Music Voice Hunt 1 and ended with the audition at the age of 18. In the year 2008, A.R Rahman heard Gopalan sang one of her original compositions. She sang at a recording studio in Chennai. Rahman was impressed to what he heard and asked one of his team members to get her contact number. She was so excited that she gave him a wrong number. She thought it was the end of her career but luckily, destiny has other plans for her. Several days later, one of her friends told her to get to Rahman’s studio immediately. She joined Rahman as a backing vocalist. Gopalan also sang for movies such as Endhiran, Jhoota hi Sahi, and Naan.